"Leucovorin is used to" prevent harmful effects of methotrexate " (Rheumatrex, Trexall; cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. "

" Leucovorin is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. Leucovorin may also be used to treat a certain type of anaemia (due to folic acid deficiency) when folic acid cannot be taken by mouth."

Dosing for leucovorin

• "Methotrexate toxicity: The starting dose is 15 mg by mouth every 6 hours until your methotrexate levels are low enough."
• "Overdose of anti-folate medications: The recommended dose is 5 mg to 15 mg by mouth a day."
• "This medication is given by injection into a vein or a muscle as directed by your doctor, usually every 6 hours or once daily. Do not inject this medication into the spine."
• "The dosage is based on your medical condition and response to treatment."

Side Effects:

Injection site reactions (pain, swelling, redness) are common side effects of this medicine. Regular blood tests are required to check your blood cells and serum methotrexate concentration in blood.